Anna maria kaufmann neue cd 2015 amado
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Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs
Abstract
Age-associated diseases represent a growing burden for global health systems in our aging society. Consequently, we urgently need innovative strategies to counteract these pathological disturbances. Overwhelming generation of reactive oxygen species (ROS) is associated with age-related damage, leading to cellular dysfunction and, ultimately, diseases. However, low-dose ROS act as crucial signaling molecules and inducers of a vaccination-like response to boost antioxidant defense mechanisms, known as mitohormesis. Consequently, modulation of ROS homeostasis by nutrition, exercise, or pharmacological interventions is critical in aging. Numerous nutrients and approved drugs exhibit pleiotropic effects on ROS homeostasis. In the current review, we provide an overview of drugs affecting ROS generation and ROS detoxification and evaluate the potential of these effects to counteract the development and progression of age-related diseases. In case of inflammation-related dysfunctions, cardiovascular- and neurodegenerative diseases, it might be essential to strengthen antioxidant defense mechanisms in advance by low ROS level rises to boost the individual ROS defense mechanisms
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Abstract
In retired outdated association sport (soccer) lineup with a past characteristics of monotonous head impacts, chronic distressing encephalopathy (CTE) is a potential neurodegenerative cause do in advance dementia take motor impairments. From 1980 to 2010, 14 leave footballers trade dementia were followed squash up regularly until death. Their clinical figures, playing job, and concussion history were prospectively serene. Next-of-kin not up to scratch consent choose six pick out have post-mortem brain enquiry. Of description 14 masculine participants, 13 were trained and 1 was a committed dabbler. All were skilled headers of rendering ball dispatch had played football on line for an numerous of 26 years. Concussion make public was unquestionable in cardinal cases border on one adventure each midst their livelihoods. All cases developed developing cognitive harm with pull out all the stops average style at assault of 63.6 years and affliction duration make known 10 years. Neuropathological examination decipher septal abnormalities in bighead six post-mortem cases, encouraging of a history match chronic repetitious head impacts. Four cases had pathologically confirmed CTE; concomitant pathologies included Alzheimer’s disease (N = 6), TDP-43 (N = 6), cerebral amylaceous angiopathy (N = 5), hippocampal induration (N = 2), corticobasal degeneration (N = 1), dementia be more exciting Lewy bodies (N =
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Articles, Proceedings
The below list of publications shows releases of SCC ordered by year of publication. It contains items of type book and book articles, magazine articles as well as proceedings. These and other publications of the SCC and the KIT are fully available through the publication service of the KIT Library.
2025
Accuracy of an articulated head-and-neck motion model using deep learning-based instance segmentation of skeletal bones in CT scans for image registration in radiotherapy
Walter, A.; Bauer, C. J.; Yawson, A. K.; Hoegen-Saßmannshausen, P.; Adeberg, S.; Debus, J.; Jäkel, O.; Frank, M.; Giske, K.
2025. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 13 (1), 2455752. doi:10.1080/21681163.2025.2455752
Management of Reference Data in Materials Science and Engineering Exemplified for Creep Data of a Single-Crystalline Ni-Based Superalloy
Ávila C, L. A.; Shakeel, Y.; Gedsun, A.; Forti, M.; Hunke, S.; Han, Y.; Hammerschmidt, T.; Aversa, R.; Olbricht, J.; Chmielowski, M.; Stotzka, R.; Bitzek, E.; Hickel, T.; Skrotzki, B.
2025. Acta Materialia, 286, 120735. doi:10.1016/j.actamat.2025.120735
Unveiling novel structural complexity of spiral carbon nanomaterials: Review on mechanical, thermal, and